15+ Powerful Bible Verses About It Is Well With My Soul


Life doesn’t always go the way we plan. We face heartache, loss, fear, and uncertainty. But in the midst of these trials, there is a deep peace that can only come from God—a calm assurance that allows us to say, “It is well with my soul.”

The phrase was made famous by the beloved hymn written by Horatio Spafford after a tragic personal loss, but its truth is grounded in Scripture. The Bible is full of verses that remind us that peace doesn’t come from our circumstances—it comes from God’s unshakable presence, love, and promises.

This collection of Bible verses will help you reflect on how to find spiritual peace, rest, and confidence through your faith, even when life is hard. Let these words breathe life into your soul and give you the assurance to say, “It is well.”

1. Isaiah 26:3

Thou wilt keep him in perfect peace, whose mind is stayed on thee: because he trusteth in thee.

Explanation:
True peace comes from focusing on God, not on life’s chaos. When we center our thoughts on Him, He surrounds us with unshakable calm.


2. John 14:27

Peace I leave with you, my peace I give unto you: not as the world giveth, give I unto you. Let not your heart be troubled, neither let it be afraid.

Explanation:
Jesus offers a peace that the world cannot give. It’s a lasting peace that calms our fears and settles our hearts in any situation.


3. Philippians 4:6–7

Be careful for nothing; but in every thing by prayer and supplication with thanksgiving let your requests be made known unto God.
And the peace of God, which passeth all understanding, shall keep your hearts and minds through Christ Jesus.

Explanation:
When we bring our worries to God through prayer, He gives us peace that goes beyond human understanding. That peace protects our heart and mind.


4. Psalm 46:1–2

God is our refuge and strength, a very present help in trouble.
Therefore will not we fear, though the earth be removed, and though the mountains be carried into the midst of the sea.

Explanation:
Even in life’s most terrifying moments, God is near. His strength and presence give us the courage to remain calm and confident.


5. Romans 8:28

And we know that all things work together for good to them that love God, to them who are the called according to his purpose.

Explanation:
Knowing that God is working for our good—even in painful circumstances—brings peace to the soul and strength to endure.


6. Matthew 11:28–29

Come unto me, all ye that labour and are heavy laden, and I will give you rest.
Take my yoke upon you, and learn of me… and ye shall find rest unto your souls.

Explanation:
Jesus invites us to give Him our burdens. When we do, we experience rest—not just physically, but deep within our soul.


7. Psalm 62:5

My soul, wait thou only upon God; for my expectation is from him.

Explanation:
This verse encourages us to wait on God in silence and trust. He alone is the source of lasting hope and peace.


8. Colossians 3:15

And let the peace of God rule in your hearts…

Explanation:
Peace isn’t just a feeling—it’s something we allow to take charge in our hearts. God’s peace should be the guiding force in our lives.


9. 2 Corinthians 4:8–9

We are troubled on every side, yet not distressed; we are perplexed, but not in despair;
Persecuted, but not forsaken; cast down, but not destroyed.

Explanation:
Life can knock us down, but with God, we are never destroyed. This verse shows the inner strength and peace that faith brings.


10. Lamentations 3:22–23

It is of the Lord’s mercies that we are not consumed, because his compassions fail not.
They are new every morning: great is thy faithfulness.

Explanation:
Each day comes with fresh mercy. Even in suffering, God’s love never fails, and His faithfulness renews our souls.


11. Psalm 23:1–3

The Lord is my shepherd; I shall not want.
He maketh me to lie down in green pastures: he leadeth me beside the still waters.
He restoreth my soul…

Explanation:
God gently leads and restores us. His care provides peace, comfort, and strength, no matter what we face.


12. Job 22:21

Acquaint now thyself with him, and be at peace: thereby good shall come unto thee.

Explanation:
Peace is the result of drawing close to God. When we know Him, we discover the quiet confidence that can settle our souls.


13. Psalm 34:18

The Lord is nigh unto them that are of a broken heart; and saveth such as be of a contrite spirit.

Explanation:
God is close when we are hurting. His nearness is a comfort, a healing balm for brokenness, and a reminder that we are never alone.


14. Romans 15:13

Now the God of hope fill you with all joy and peace in believing…

Explanation:
When we believe in God’s promises, He fills us with hope and peace. This verse encourages us to trust in His goodness.


15. 2 Thessalonians 3:16

Now the Lord of peace himself give you peace always by all means…

Explanation:
God is the source of peace in every way, at all times. This is a blessing over our lives, assuring us that peace is possible regardless of circumstances.

When Your Soul Is Anchored in Christ

These Bible verses about “It is well with my soul” offer deep reassurance for anyone walking through sorrow, stress, or spiritual struggle. They are reminders that peace isn’t dependent on how good life is going—it’s grounded in how good God is.

When storms come—and they will—God invites us to rest in Him. Through prayer, Scripture, and trust, we can say with confidence: “It is well with my soul.”

Now it’s your turn:
Which verse helped you feel peace today? Have you ever experienced calm in the middle of your storm through God’s promises? Share your favorite Bible verse about “It is well with my soul” or your personal story in the comments below. Your words could be just what someone else needs to hear.